circRNA basic information
circBase ID: hsa_circ_0000520
Name: hsa_circ_RPPH1
Synonym: -
Host Gene: hsa-miR-1296
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: CDK2
Associated microRNA: hsa-miR-1296
Biological function: Silencing hsa_circ_0000520 inhibited cervical cancer cell proliferation and promoted the inhibitory effects of miR-1296 on CDK2, thereby blocking cell cycle progression and promoting apoptosis
Molecular mechanism: Silencing hsa_circ_0000520 inhibited cervical cancer cell proliferation and promoted the inhibitory effects of hsa-miR-1296 on CDK2, thereby blocking cell cycle progression and promoting apoptosis
Survival: -
Supported No.:
 2
Description:

Silencing hsa_circ_0000520 inhibited cervical cancer cell proliferation and promoted the inhibitory effects of miR-1296 on CDK2, thereby blocking cell cycle progression and promoting apoptosis.
Other information
Title:

Hsa_circ_0000520 overexpression increases CDK2 expression via miR-1296 to facilitate cervical cancer cell proliferation.

Journal: J Transl Med
Published: 2021/7/22
PubMed ID: 34284793