circRNA basic information
circBase ID: -
Name: hsa_circ_FBXL5
Synonym: CircFBXL5
Host Gene: hsa-miR-216b
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: breast cancer cell lines (MDA-MB-453, MDAMB-231)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HMGA2
Associated microRNA: hsa-miR-216b
Biological function: circFBXL5 knockdown inhibited the 5-FU resistance of breast cancer by inhibiting cell migration, invasion and promoting apoptosis
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 2
Description:

circFBXL5 could promote the 5-FU resistance of breast cancer by regulating miR-216b/HMGA2 axis.
Other information
Title:

CircFBXL5 promotes the 5-FU resistance of breast cancer via modulating miR-216b/HMGA2 axis.

Journal: Cancer Cell Int
Published: 2021/7/21
PubMed ID: 34281530