circRNA basic information
circBase ID: -
Name: -
Synonym: circ_001422
Host Gene: hsa-miR-195-5p
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: FGF2/PI3K/Akt
Associated microRNA: hsa-miR-195-5p
Biological function: Circ_001422 knockdown markedly repressed the proliferation and metastasis and promoted the apoptosis of OS cells in vivo and in vitro
Molecular mechanism: competitive interactions between circ_001422 and hsa-miR-195-5p elevated FGF2 expression while also initiating PI3K/Akt signaling
Survival: poor
Supported No.:
 1
Description:

Circ_001422 accelerates OS tumorigenesis and metastasis by modulating the miR-195-5p/FGF2/PI3K/Akt axis, implying that circ_001422 can be therapeutically targeted to treat OS.
Other information
Title:

Circular RNA circ_001422 promotes the progression and metastasis of osteosarcoma via the miR-195-5p/FGF2/PI3K/Akt axis.

Journal: J Exp Clin Cancer Res
Published: 2021/7/18
PubMed ID: 34271943