circRNA basic information
circBase ID: -
Name: hsa_circ_SLC6A6
Synonym: circSLC6A6
Host Gene: hsa-miR-497-5p
 
 
 
Disease basic information
DO ID:
 1380
DO name: endometrial cancer
Disease details: endometrial cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PI4KB/hedgehog pathway
Associated microRNA: hsa-miR-497-5p
Biological function: circSLC6A6 promoted the proliferation, migration, and invasion of EC cells in vitro. In vivo, circSLC6A6 promoted tumor growth
Molecular mechanism: circSLC6A6 could regulate tumor-associated signaling PI4KB/hedgehog pathway by sponging hsa-miR-497-5p
Survival: -
Supported No.:
 1
Description:

We found that circSLC6A6 was highly expressed in both EC tissues and cells. And circSLC6A6 promoted the proliferation, migration, and invasion of EC cells in vitro. In vivo, circSLC6A6 promoted tumor growth. Besides, a mechanistic study demonstrated that circSLC6A6 could regulate tumor-associated signaling PI4KB/hedgehog pathway by sponging miR-497-5p.

Other information
Title:

circSLC6A6 Sponges miR-497-5p to Promote Endometrial Cancer Progression via the PI4KB/Hedgehog Axis.

Journal: J Immunol Res
Published: 2021/7/15
PubMed ID: 34258297