circRNA basic information
circBase ID: -
Name: hsa_circ_TLK1
Synonym: circTLK1
Host Gene: hsa-miR-106a-5p
 
 
 
Disease basic information
DO ID:
 3021
DO name: acute kidney failure
Disease details: acute kidney injury
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: HK-2 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HMGB1
Associated microRNA: hsa-miR-106a-5p
Biological function: The circTLK1 knockdown repressed oxidation stress, inflammation, and apoptosis in the sepsis-related AKI rat model.
Molecular mechanism: CircTLK1 enhanced HMGB1 expression by sponging miR-106a-5p in the HK-2 cells, and miR-106a-5p and HMGB1 were involved in circTLK1-meidated injury of LPS-treated cells.
Survival: -
Supported No.:
 1
Description:

we concluded that circTLK1 contributed to sepsis-associated AKI by regulating inflammation and oxidative stress through the miR-106a-5p/HMGB1 axis. CircTLK1 and miR-106a-5p may be employed as the potential targets for the treatment of AKI.
Other information
Title:

Circular RNA TLK1 Promotes Sepsis-Associated Acute Kidney Injury by Regulating Inflammation and Oxidative Stress Through miR-106a-5p/HMGB1 Axis.

Journal: Front Mol Biosci
Published: 2021/7/13
PubMed ID: 34250012