circRNA basic information
circBase ID: -
Name: hsa_circ_STIL
Synonym: circ-STIL
Host Gene: hsa-miR-345-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: AQP3
Associated microRNA: hsa-miR-345-5p
Biological function: Circ-STIL knockdown inhibited HCC cell progression by reducing cell proliferation, migration and invasion and promoting cell apoptosis
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

Circ-STIL knockdown or miR-345-5p overexpression impeded cell malignant behaviors in HCC cells, and the effects could be reversed by miR-345-5p silence or AQP3 enhancement, respectively. Meanwhile, circ-STIL regulated AQP3 expression by sponging miR-345-5p. Besides, circ-STIL downregulation retarded HCC tumor growth in vivo.
Other information
Title:

Circular RNA Circ-STIL Contributes to Cell Growth and Metastasis in Hepatocellular Carcinoma via Regulating miR-345-5p/AQP3 Axis.

Journal: Dig Dis Sci
Published: 2021/7/8
PubMed ID: 34231101