circRNA basic information
circBase ID: hsa_circ_0001821
Name: -
Synonym: Circ_0001821
Host Gene: hsa-miR-526b-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: GRK5
Associated microRNA: hsa-miR-526b-5p
Biological function: Circ_0001821 knockdown reduced colony formation ability and metastasis ability but enhanced TAX sensibility and apoptosis of NSCLC cells
Molecular mechanism: Circ_0001821 could upregulate GRK5 expression by sponging hsa-miR-526b-5p
Survival: -
Supported No.:
 1
Description:

Depletion of circ_0001821 also blocked tumor growth in vivo. In conclusion, the depletion of circ_0001821 inhibited NSCLC progression, at least in part, by modulating the miR-526b-5p/GRK5 axis.
Other information
Title:

Circ_0001821 knockdown suppresses growth, metastasis, and TAX resistance of non-small-cell lung cancer cells by regulating the miR-526b-5p/GRK5 axis.

Journal: Pharmacol Res Perspect
Published: 2021/7/6
PubMed ID: 34219377