circRNA basic information
circBase ID: -
Name: hsa_circ_DOCK5
Synonym: circ-DOCK5
Host Gene: hsa-miR-627-3p
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: TGFB2
Associated microRNA: hsa-miR-627-3p
Biological function: -
Molecular mechanism: -
Survival: better
Supported No.:
 1
Description:

ZEB1-mediated downregulation of circ-DOCK5 facilitates metastasis in ESCC by forming a positive feedback loop with TGF-beta by altering the miR-627-3p/TGFB2 signaling. Targeting this signaling pathway may help suppress progression in ESCC.
Other information
Title:

ZEB1 represses biogenesis of circ-DOCK5 to facilitate metastasis in esophageal squamous cell carcinoma via a positive feedback loop with TGF-beta.

Journal: Cancer Lett
Published: 2021/7/4
PubMed ID: 34216686