circRNA basic information
circBase ID: -
Name: hsa_circ_ITCH
Synonym: circ-ITCH
Host Gene: hsa-miR-33a-5p
 
 
 
Disease basic information
DO ID:
 9743
DO name: diabetic neuropathy
Disease details: Diabetic nephropathy
Species: human
Species details: human
Sample type: cell line
Sample type details: rat mesangial cells,_DX
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: SIRT6
Associated microRNA: hsa-miR-33a-5p
Biological function: Circ-ITCH overexpression inhibited the viability, migration, fibrosis and inflammatory response of HG-induced RMCs.
Molecular mechanism: Further experiments confirmed that miR-33a-5p may be a direct target of circ-ITCH and SIRT6 may be a direct target of miR-33a-5p.
Survival: -
Supported No.:
 1
Description:

In conclusion, circ-ITCH alleviated renal inflammation and fibrosis in STZ-induced diabetic mice by regulating the miR-33a-5p/SIRT6 axis.
Other information
Title:

CircRNA circ-ITCH improves renal inflammation and fibrosis in streptozotocin-induced diabetic mice by regulating the miR-33a-5p/SIRT6 axis.

Journal: Inflamm Res
Published: 2021/7/4
PubMed ID: 34216220