circRNA basic information
circBase ID: -
Name: hsa_circ_CSPP1
Synonym: Circ-CSPP1
Host Gene: hsa-miR-493-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: HMGB1
Associated microRNA: hsa-miR-493-5p
Biological function: Circ-CSPP1 knockdown not only depleted HCC cell proliferation, formation, migration and invasion in vitro but also inhibited tumor growth in vivo
Molecular mechanism: Circ-CSPP1 sponged hsa-miR-493-5p to regulate HMGB1 expression
Survival: -
Supported No.:
 6
Description:

Knockdown of circ-CSPP1 suppressed HCC development both in vitro and in vivo by upregulation of miR-493-5p and downregulation of HMGB1, hinting that circ-CSPP1 participated in HCC pathogenesis.
Other information
Title:

Circ-CSPP1 knockdown suppresses hepatocellular carcinoma progression through miR-493-5p releasing-mediated HMGB1 downregulation.

Journal: Cell Signal
Published: 2021/6/29
PubMed ID: 34182091