circRNA basic information
circBase ID: -
Name: hsa_circ_ACTR2
Synonym: circ-ACTR2
Host Gene: hsa-miR-205-5p
 
 
 
Disease basic information
DO ID:
 9743
DO name: diabetic neuropathy
Disease details: Diabetic nephropathy
Species: human
Species details: human
Sample type: cell line
Sample type details: human renal mesangial cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HMGA2
Associated microRNA: hsa-miR-205-5p
Biological function: Silencing the circ-ACTR2 expression partly abolished the HG-induced cell proliferation, inflammation and extracellular matrix accumulation and oxidative stress in HRMCs.
Molecular mechanism: Circ-ACTR2 was confirmed as a sponge for miR-205-5p. Circ-ACTR2 regulated the effects of HG on HRMCs by targeting miR-205-5p.
Survival: -
Supported No.:
 1
Description:

All data have manifested that circ-ACTR2 contributed to the HG-induced DN progression in HRMCs by the mediation of miR-205-5p/HMGA2 axis.
Other information
Title:

Circ-ACTR2 aggravates the high glucose-induced cell dysfunction of human renal mesangial cells through mediating the miR-205-5p/HMGA2 axis in diabetic nephropathy.

Journal: Diabetol Metab Syndr
Published: 2021/6/28
PubMed ID: 34174955