circRNA basic information
circBase ID: hsa_circ_0084043
Name: -
Synonym: circ_0084043
Host Gene: hsa-miR-128-3p
 
 
 
Disease basic information
DO ID:
 9351
DO name: diabetes mellitus
Disease details: diabetes mellitus
Species: human
Species details: human
Sample type: cell line
Sample type details: ARPE-19 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TXNIP
Associated microRNA: hsa-miR-128-3p
Biological function: Circ_0084043 knockdown or miR-128-3p overexpression mitigated the HG-mediated cell viability inhibition, apoptosis promotion, and inflammatory response.
Molecular mechanism: Circ_0084043 regulated the TXNIP expression to activate Wnt/beta-catenin signal pathway by targeting miR-128-3p.
Survival: -
Supported No.:
 1
Description:

circ_0084043 promoted the HG-induced retinal pigment epithelial cell injury through activating the Wnt/beta-catenin signal pathway by the miR-128-3p/TXNIP axis.
Other information
Title:

Circ_0084043 Facilitates High Glucose-Induced Retinal Pigment Epithelial Cell Injury by Activating miR-128-3p/TXNIP-Mediated Wnt/beta-Catenin Signaling Pathway.

Journal: J Cardiovasc Pharmacol
Published: 2021/6/27
PubMed ID: 34173806