circRNA basic information
circBase ID: -
Name: -
Synonym: Circ3823
Host Gene: hsa-miR-30c-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: TCF7
Associated microRNA: hsa-miR-30c-5p
Biological function: -
Molecular mechanism: circ3823 act as a competing endogenous RNA of hsa-miR-30c-5p to relieve the repressive effect of hsa-miR-30c-5p on its target TCF7 which upregulates MYC and CCND1
Survival: poor
Supported No.:
 1
Description:

circ3823 promotes CRC growth, metastasis and angiogenesis through circ3823/miR-30c-5p/TCF7 axis and it may serve as a new diagnostic marker or target for treatment of CRC patients. In addition, m6A modification is involved in regulating the degradation of circ3823.
Other information
Title:

Circ3823 contributes to growth, metastasis and angiogenesis of colorectal cancer: involvement of miR-30c-5p/TCF7 axis.

Journal: Mol Cancer
Published: 2021/6/27
PubMed ID: 34172072