circRNA basic information
circBase ID: -
Name: hsa_circ_LRP6
Synonym: CircLRP6
Host Gene: hsa-miR-330-5p
 
 
 
Disease basic information
DO ID:
 10283
DO name: prostate cancer
Disease details: prostate cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: NRBP1
Associated microRNA: hsa-miR-330-5p
Biological function: knockdown of circLRP6 impaired PCa cell growth and metastasis in vitro by affecting cell proliferation, apoptosis, invasion, migration, and epithelial-mesenchymal transition (EMT)
Molecular mechanism: circLRP6 could competitively bind with hsa-miR-330-5p to prevent the degradation of its target gene NRBP1
Survival: -
Supported No.:
 1
Description:

circLRP6 promoted PCa tumorigenesis and metastasis through miR-330-5p/NRBP1 axis, suggesting a potential therapeutic target for PCa.
Other information
Title:

CircLRP6 contributes to prostate cancer growth and metastasis by binding to miR-330-5p to up-regulate NRBP1.

Journal: World J Surg Oncol
Published: 2021/6/24
PubMed ID: 34158077