circRNA basic information
circBase ID: -
Name: hsa_circ_MAPK9
Synonym: CircMAPK9
Host Gene: hsa-miR-140-3p
 
 
 
Disease basic information
DO ID:
 7148
DO name: rheumatoid arthritis
Disease details: rheumatoid arthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PPM1A
Associated microRNA: hsa-miR-140-3p
Biological function: CircMAPK9 silence suppressed cell proliferation, migration, invasion, inflammatory response, and promoted apoptosis in RA-FLSs
Molecular mechanism: circMAPK9 could regulate PPM1A expression by sponging hsa-miR-140-3p
Survival: -
Supported No.:
 2
Description:

CircMAPK9 knockdown might inhibit cell proliferation, migration, invasion, inflammatory response, and facilitate apoptosis in RA-FLSs via regulating miR-140-3p/PPM1A axis, offering a new mechanism for the comprehension of RA development and a new insight into the potential application of circMAPK9 in RA treatment.
Other information
Title:

CircMAPK9 promotes the progression of fibroblast-like synoviocytes in rheumatoid arthritis via the miR-140-3p/PPM1A axis.

Journal: J Orthop Surg Res
Published: 2021/6/23
PubMed ID: 34154607