circRNA basic information
circBase ID: hsa_circ_0042823
Name: hsa_circ_SSH2
Synonym: -
Host Gene: hsa-miR-877-5p
 
 
 
Disease basic information
DO ID:
 2876
DO name: laryngeal squamous cell carcinoma
Disease details: laryngeal squamous cell carcinoma
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: LSCC cell lines (AMC-HN-8, TU686)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FOXM1
Associated microRNA: hsa-miR-877-5p
Biological function: promoted proliferation, migration and invasion
Molecular mechanism: Hsa_circ_0042823 promoted the expression of FOXM1 via its ceRNA activity on hsa-miR-877-5p
Survival: -
Supported No.:
 1
Description:

Hsa_circ_0042823 promotes FOXM1 expression by sponging miR-877-5p.Hsa_circ_0042823 promotes proliferation, migration, invasion of LSCC cells.Hsa_circ_0042823 knockdown inhibits tumour growth of LSCC via miR-877-5p/FOXM1 axis.
Other information
Title:

Hsa_circ_0042823 accelerates cancer progression via miR-877-5p/FOXM1 axis in laryngeal squamous cell carcinoma.

Journal: Ann Med
Published: 2021/6/15
PubMed ID: 34124974