circRNA basic information
circBase ID: hsa_circ_0091702
Name: -
Synonym: circ_0091702
Host Gene: hsa-miR-545-3p
 
 
 
Disease basic information
DO ID:
 3021
DO name: acute kidney failure
Disease details: acute kidney injury
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HK2 cell
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: THBS2
Associated microRNA: hsa-miR-545-3p
Biological function: Circ_0091702 could attenuate LPS-induced HK2 cell injury, while its silencing had an opposite effect.
Molecular mechanism: circ_0091702 could act as a sponge of miR-545-3p, and miR-545-3p could directly target THBS2.
Survival: -
Supported No.:
 1
Description:

In conclusion, our results showed that circ_0091702 could suppress LPS-induced HK2 cell injury via the miR-545-3p/THBS2 axis, indicating that circ_0091702 might be an important biomarker for relieving sepsis-related AKI.
Other information
Title:

Circ_0091702 serves as a sponge of miR-545-3p to attenuate sepsis-related acute kidney injury by upregulating THBS2.

Journal: J Mol Histol
Published: 2021/6/9
PubMed ID: 34101064