circRNA basic information
circBase ID: -
Name: mmu_circ_Prkcsh
Synonym: circPrkcsh
Host Gene: mmu-miR-488
 
 
 
Disease basic information
DO ID:
 13743
DO name: spinal cord lipoma
Disease details: spinal cord injury
Species: mouse
Species details: mouse
Sample type: PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: Ccl2
Associated microRNA: mmu-miR-488
Biological function: circPrkcsh knockdown decreased the expression of Ccl2 by upregulating miR-488 expression, and reduced the secretion of inflammatory cytokines in vitro.
Molecular mechanism: circPrkcsh knockdown decreased the expression of Ccl2 by upregulating miR-488 expression
Survival: -
Supported No.:
 2
Description:

circPrkcsh may be used as an miR-488 sponge to regulate Ccl2 expression, which might provide a new potential therapy for SCI.
Other information
Title:

Down-regulating Circular RNA Prkcsh suppresses the inflammatory response after spinal cord injury.

Journal: Neural Regen Res
Published: 2021/6/9
PubMed ID: 34100450