circRNA basic information
circBase ID: hsa_circ_0000615
Name: -
Synonym: circ_0000615
Host Gene: hsa-miR-646
 
 
 
Disease basic information
DO ID:
 8947
DO name: diabetic retinopathy
Disease details: Diabetic retinopathy
Species: human
Species details: human
Sample type: cell line
Sample type details: human retinal pigment epithelium (HRPE) cells.
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: YAP1
Associated microRNA: hsa-miR-646
Biological function: Knockdown of circ_0000615 attenuated HG-triggered HRPE cell apoptosis, inflammation, and ROS generation.
Molecular mechanism: miR-646 was confirmed to be a target of circ_0000615, inhibition of miR-646 reversed the protective effects of circ_0000615 knockdown on HG-evoked HRPE cell dysfunction. MiR-646 was verified to target YAP1, overexpression of YAP1 abolished the impairment induced by miR-646 on HG-induced HRPE cell damage.
Survival: -
Supported No.:
 2
Description:

Circ_0000615 contributed to HG-induced HRPE cell dysfunction via miR-646/YAP1 axis, suggesting a novel insight into the pathogenesis of DR and a potential candidate for DR treatment.
Other information
Title:

Circ_0000615 promotes high glucose-induced human retinal pigment epithelium cell apoptosis, inflammation and oxidative stress via miR-646/YAP1 axis in diabetic retinopathy.

Journal: Eur J Ophthalmol
Published: 2021/6/8
PubMed ID: 34096368