circRNA basic information
circBase ID: -
Name: hsa_circ_HACE1
Synonym: CircHACE1
Host Gene: hsa-miR-346
 
 
 
Disease basic information
DO ID:
 1781
DO name: thyroid gland cancer
Disease details: thyroid cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: Tfcp2L1
Associated microRNA: hsa-miR-346
Biological function: CircHACE1 overexpression decreased xenograft tumor growth in vivo and induced cell cycle arrest, apoptosis, impeded proliferation, migration, and invasion in differentiated THCA cells in vitro
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

circHACE1 adsorbed miR-346 and elevated Tfcp2L1 expression, thus curbing cell malignancy in differentiated THCA.
Other information
Title:

CircHACE1 functions as a competitive endogenous RNA to curb differentiated thyroid cancer progression by upregulating Tfcp2L1 through adsorbing miR-346.

Journal: Endocr J
Published: 2021/6/8
PubMed ID: 34092745