circRNA basic information
circBase ID: -
Name: hsa_circ_HIPK3
Synonym: circHIPK3
Host Gene: hsa-miR-192, hsa-miR-561
 
 
 
Disease basic information
DO ID:
 13189
DO name: gout
Disease details: gouty arthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: THP-1 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TLR4 and NLRP3
Associated microRNA: hsa-miR-192, hsa-miR-561
Biological function: circHIPK3 overexpression promoted the inflammatory cytokines levels in MSU-stimulated THP-1 cells, and circHIPK3 silencing obtained the opposite effect
Molecular mechanism: circHIPK3 sponged hsa-miR-192 and hsa-miR-561, and subsequently promoted the expressions of hsa-miR-192 and hsa-miR-561 target gene TLR4 and NLRP3
Survival: -
Supported No.:
 1
Description:

circHIPK3 sponges miR-192 and miR-561 to promote TLR4 and NLRP3 expressions, thereby promoting inflammatory response in gouty arthritis.
Other information
Title:

Circular RNA circHIPK3 Activates Macrophage NLRP3 Inflammasome and TLR4 Pathway in Gouty Arthritis via Sponging miR-561 and miR-192.

Journal: Inflammation
Published: 2021/6/5
PubMed ID: 34085163