circRNA basic information
circBase ID: -
Name: hsa_circ_NSUN2
Synonym: circNSUN2
Host Gene: hsa-miR-181a-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human normal colonic epithelial cell line (NCM460), colorectal cancer cell line (HCT116), colorectal cancer cell line (DiFi), colorectal cancer cell line (HROC18), colorectal cancer cell line (T84), 293T cells.
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ROCK2
Associated microRNA: hsa-miR-181a-5p
Biological function: Knockdown of circNSUN2 inhibited proliferation and migration, and induced apoptosis of CRC cells and suppressed tumor growth by targeting miR_181a_5p to decrease ROCK2 expression
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 3
Description:

circNSUN2 promoted the progression of CRC by sponging miR_181a_5p to increase the expression of ROCK2.
Other information
Title:

circNSUN2 promotes the malignant biological behavior of colorectal cancer cells via the miR_181a_5p/ROCK2 axis.

Journal: Oncol Rep
Published: 2021/6/4
PubMed ID: 34080658