circRNA basic information
circBase ID: hsa_circ_0001666
Name: hsa_circ_FAM120B
Synonym: -
Host Gene: hsa-miR-1251
 
 
 
Disease basic information
DO ID:
 1793
DO name: pancreatic cancer
Disease details: pancreatic cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human PC cell lines (AsPC-1, PANC-1, SW-1990, PaCa-2), immortalized human pancreatic duct epithelial cell line (HPDE6-C7)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SOX4
Associated microRNA: hsa-miR-1251
Biological function: upregulation of circ_0001666 facilitates PC cell proliferation, EMT and invasiveness, whereas knockdown of circ_0001666 exhibits opposite functions
Molecular mechanism: circ_0001666 is able to bind to hsa-miR-1251, thus increasing the expression of SOX4, which is a direct downstream effector of hsa-miR-1251
Survival: poor
Supported No.:
 1
Description:

circ_0001666 acts as an oncogenic circRNA to promote EMT and invasion of PC cells through sponging miR-1251, and indicated that circ_0001666 could be explored as a potential therapeutic target for PC.
Other information
Title:

Silencing of circRNA circ_0001666 Represses EMT in Pancreatic Cancer Through Upregulating miR-1251 and Downregulating SOX4.

Journal: Front Mol Biosci
Published: 2021/6/1
PubMed ID: 34055896