circRNA basic information
circBase ID: -
Name: hsa_circ_ARL8B
Synonym: CircARL8B
Host Gene: hsa-miR-653-5p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: MCF-10A cells, BC cells (MCF-7, MDA-MB-231)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HMGA2
Associated microRNA: hsa-miR-653-5p
Biological function: CircARL8B silencing inhibited cell viability, migration, invasion and fatty acid metabolism in BC cells in vitro and blocked tumor growth in vivo
Molecular mechanism: hsa-miR-653-5p/HMGA2 axis
Survival: -
Supported No.:
 2
Description:

circARL8B knockdown might block PGE2/PI3K/AKT/GSK-3beta/Wnt/beta-catenin pathway. Silencing of circARL8B inhibited cell viability, migration, invasion and fatty acid metabolism via miR-653-5p/HMGA2 axis in BC.
Other information
Title:

CircARL8B Contributes to the Development of Breast Cancer Via Regulating miR-653-5p/HMGA2 Axis.

Journal: Biochem Genet
Published: 2021/5/30
PubMed ID: 34050452