circRNA basic information
circBase ID: -
Name: hsa_circ_MYBL2
Synonym: CircMYBL2
Host Gene: hsa-miR-665
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human CC cell lines (C-33A, CaSki, SiHa, HeLa), normal cervical epithelium cell line (HcerEpic), PTX-resistant CC cell line (HeLa/ PTX)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: EGFR
Associated microRNA: hsa-miR-665
Biological function: -
Molecular mechanism: -
Survival: -
Supported No.:
 2
Description:

CircMYBL2 played a positive role in the PTX resistance and malignant activities of PTX-sensitive and PTX-resistant CC cells by regulating the miR-665/EGFR network, providing a novel therapeutic strategy for the treatment of CC patients resistant to PTX.
Other information
Title:

CircMYBL2 regulates the resistance of cervical cancer cells to paclitaxel via miR-665-dependent regulation of EGFR.

Journal: Drug Dev Res
Published: 2021/5/29
PubMed ID: 34046939