circRNA basic information
circBase ID: hsa_circ_0001944
Name: -
Synonym: Circ_0001944
Host Gene: hsa-miR-142-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal lung epithelial cells (BEAS-2B), NSCLC cells (A549, H1975, H522, HCC827)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: NFAT5
Associated microRNA: hsa-miR-142-5p
Biological function: Circ_0001944 silencing decreased xenograft tumor growth in vivo and repressed proliferation, migration, invasion, and glycolysis of NSCLC cells in vitro
Molecular mechanism: adsorbed hsa-miR-142-5p to elevate NFAT5 expression
Survival: -
Supported No.:
 1
Description:

Circ_0001944 promotes proliferation, migration, invasion, and glycolysis of NSCLC cells by upregulating NFAT5 through adsorbing miR-142-5p, offering a novel mechanism for understanding the advancement of NSCLC.
Other information
Title:

Circ_0001944 Contributes to Glycolysis and Tumor Growth by Upregulating NFAT5 Through Acting as a Decoy for miR-142-5p in Non-Small Cell Lung Cancer.

Journal: Cancer Manag Res
Published: 2021/5/28
PubMed ID: 34040437