circRNA basic information
circBase ID: hsa_circ_0001367
Name: -
Synonym: Circ_0001367
Host Gene: hsa-miR-431
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal human astrocytes (NHAs), glioma cell lines (A172, LN229, T98G, U118, U138)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: NRXN3
Associated microRNA: hsa-miR-431
Biological function: suppress the proliferation, migration and invasion of glioma cells in vitro and inhibit glioma growth in vivo
Molecular mechanism: circ_0001367 can serve as a sponge for hsa-miR-431 and that hsa-miR-431 acts as an oncogene by regulating neurexin 3 (NRXN3)
Survival: better
Supported No.:
 2
Description:

circ_0001367 functions as an suppressor in glioma by targeting the miR-431/NRXN3 axis and may be a promising therapeutic target against gliomas.
Other information
Title:

Circ_0001367 inhibits glioma proliferation, migration and invasion by sponging miR-431 and thus regulating NRXN3.

Journal: Cell Death Dis
Published: 2021/5/27
PubMed ID: 34035217