circRNA basic information
circBase ID: -
Name: hsa_circ_SOS2
Synonym: CircSOS2
Host Gene: hsa-miR-543
 
 
 
Disease basic information
DO ID:
 3744
DO name: cervical squamous cell carcinoma
Disease details: cervical squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human immortalized cervical squamous cells (ECT1/E6E7 cells), SCC cells (SiHa, SW756 cells)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FNDC3B
Associated microRNA: hsa-miR-543
Biological function: suppression of circSOS2 repressed proliferation, cell cycle process, migration, invasion, and glycolysis while induced apoptosis in SCC cells
Molecular mechanism: by targeting hsa-miR-543/FNDC3B axis
Survival: -
Supported No.:
 1
Description:

CircSOS2 conferred an oncogenic function in SCC by regulation of proliferation, cell cycle, apoptosis, migration, invasion, and glycolysis of SCC cells, which was contributed to its interactions with miR-543 and FNDC3B.
Other information
Title:

CircSOS2 promotes cervical squamous cell carcinoma by regulation of proliferation, cell cycle, apoptosis, migration, invasion, and glycolysis by targeting miR-543/FNDC3B axis.

Journal: Arch Biochem Biophys
Published: 2021/5/24
PubMed ID: 34023283