circRNA basic information
circBase ID: hsa_circ_0038467
Name: -
Synonym: circ_0038467
Host Gene: hsa-miR-195-5p
 
 
 
Disease basic information
DO ID:
 552
DO name: pneumonia
Disease details: pneumonia
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: MRC-5 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TLR4
Associated microRNA: hsa-miR-195-5p
Biological function: Circ_0038467 silencing restored LPS-mediated inhibition on cell proliferation and promotion on apoptosis and inflammatory response.
Molecular mechanism: circ_0038467 acted as a sponge of miR-195-5p, which was further revealed to target TLR4.
Survival: -
Supported No.:
 4
Description:

Circ_0038467 silencing protected MRC-5 cells from LPS-induced injury by miR-195-5p/TLR4 axis through NF-¦ĘB pathway, providing a theoretical basis for circRNA-directed IP therapy.
Other information
Title:

Circ_0038467 regulates lipopolysaccharide-mediated cell proliferation, apoptosis, and inflammatory response by miR-195-5p/TLR4 axis through NF-kappaB pathway in MRC-5 cells.

Journal: Biosci Biotechnol Biochem
Published: 2021/5/23
PubMed ID: 34021567