circRNA basic information
circBase ID: hsa_circ_0000745
Name: -
Synonym: Circ_0000745
Host Gene: hsa-miR-488
 
 
 
Disease basic information
DO ID:
 50866
DO name: oral squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: OSCC cell lines (Cal-27, SCC-25, SCC9, HSC3), human oral keratinocytes (HOK)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CCND1
Associated microRNA: hsa-miR-488
Biological function: Circ_0000745 downregulation inhibited OSCC cell proliferation and induced cell cycle arrest and apoptosis in vitro, as well as blocked tumor growth in vivo
Molecular mechanism: miRNA sponge
Survival: -
Supported No.:
 1
Description:

Circ_0000745 regulated the expression of CCND1 partly by acting as miR-488 sponge and interacting with HuR protein, thus promoting the progression of OSCC.
Other information
Title:

Circ_0000745 strengthens the expression of CCND1 by functioning as miR-488 sponge and interacting with HuR binding protein to facilitate the development of oral squamous cell carcinoma.

Journal: Cancer Cell Int
Published: 2021/5/23
PubMed ID: 34020639