circRNA basic information
circBase ID: -
Name: hsa_circ_AGFG1
Synonym: circAGFG1
Host Gene: hsa-miR-28-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human bronchial epithelial cell line (HBE1), a panel of four NSCLC cell lines (A549, 95-D, HCC827, H1299)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HIF-1alpha
Associated microRNA: hsa-miR-28-5p
Biological function: circAGFG1 knockdown inhibited the proliferation, migration, and invasion and promoted the apoptosis of NSCLC cells
Molecular mechanism: circAGFG1/hsa-miR-28-5p/HIF-1alpha axis
Survival: poor
Supported No.:
 2
Description:

circAGFG1 promoted the proliferation, migration, and invasion and suppressed the apoptosis of NSCLC cells through accelerating the glycolysis via miR-28-5p/HIF-1alpha axis.
Other information
Title:

circAGFG1 sponges miR-28-5p to promote non-small-cell lung cancer progression through modulating HIF-1alpha level.

Journal: Open Med (Wars)
Published: 2021/5/21
PubMed ID: 34013042