circRNA basic information
circBase ID: -
Name: hsa_circ_HIPK2
Synonym: CircHIPK2
Host Gene: hsa-miR-338-3p
 
 
 
Disease basic information
DO ID:
 2394
DO name: ovarian cancer
Disease details: ovarian cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: SKOV3/DDP, A2780/DDP cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CHTOP
Associated microRNA: hsa-miR-338-3p
Biological function: Blocking circHIPK2 could promote apoptosis and suppress the 50% inhibitory concentration (IC50) of DDP, cell proliferation, cell cycle entrance, migration and invasion in SKOV3/DDP and A2780/DDP cells.
Molecular mechanism: regulating hsa-miR-338-3p/CHTOP axis
Survival: -
Supported No.:
 3
Description:

CircHIPK2 might be a tumor promoter in OvCa and was associated with DDP resistance. Silencing circHIPK2 might suppress DDP-resistant OvCa through regulating miR-338-3p/CHTOP axis.
Other information
Title:

CircHIPK2 Contributes to DDP Resistance and Malignant Behaviors of DDP-Resistant Ovarian Cancer Cells Both in vitro and in vivo Through circHIPK2/miR-338-3p/CHTOP ceRNA Pathway.

Journal: Onco Targets Ther
Published: 2021/5/21
PubMed ID: 34012271