circRNA basic information
circBase ID: -
Name: hsa_circ_MKLN1
Synonym: CircMKLN1
Host Gene: hsa-miR-425-5p
 
 
 
Disease basic information
DO ID:
 768
DO name: retinoblastoma
Disease details: Retinoblastoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human retinal pigment epithelial cells (ARPE-19), RB cells (Y79, WERI-RB1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: PDCD4
Associated microRNA: hsa-miR-425-5p
Biological function: repressed RB cell proliferation, migration and invasion
Molecular mechanism: miRNA sponge
Survival: better
Supported No.:
 1
Description:

CircMKLN1 overexpression decelerated the progression of RB through sponging miR-425-5p and elevating PDCD4.
Other information
Title:

CircMKLN1 Suppresses the Progression of Human Retinoblastoma by Modulation of miR-425-5p/PDCD4 Axis.

Journal: Curr Eye Res
Published: 2021/5/15
PubMed ID: 33988065