circRNA basic information
circBase ID: hsa_circ_0000712
Name: hsa_circ_NFATC3
Synonym: -
Host Gene: hsa-miR-879-5p
 
 
 
Disease basic information
DO ID:
 557
DO name: kidney disease
Disease details: diabetic nephropathy
Species: human
Species details: human
Sample type: cell line
Sample type details: SV40-MES13 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SOX6
Associated microRNA: hsa-miR-879-5p
Biological function: circ_0000712 deficiency repressed HG-caused apoptosis, inflammation, oxidative stress, and fibrosis in SV40-MES13 cells
Molecular mechanism: regulate SOX6 expression by sponging hsa-miR-879-5p.
Survival: -
Supported No.:
 1
Description:

Circ_0000712 knockdown could hinder HG-inducted SV40-MES13 cell injury through targeting the miR-879-5p/SOX6 axis, implying a possible circRNA-targeted therapy for DN.
Other information
Title:

Circular RNA circ_0000712 regulates high glucose-induced apoptosis, inflammation, oxidative stress, and fibrosis in (DN) by targeting the miR-879-5p/SOX6 axis.

Journal: Endocr J
Published: 2021/5/14
PubMed ID: 33980772