circRNA basic information
circBase ID: -
Name: -
Synonym: CircRNA_2646
Host Gene: hsa-miR-124
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human normal esophageal epithelial cells (HEEC), ESCC cell lines (KYSE150, Eca109, TE-1, Eca9706)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PLP2
Associated microRNA: hsa-miR-124
Biological function: accelerated cell proliferation, migration, invasion, and epithelial-to-mesenchymal transition (EMT)
Molecular mechanism: repressing hsa-miR-124 and activating PLP2
Survival: -
Supported No.:
 1
Description:

CircRNA_2646 functioned as an inhibitor in miR-124 signaling pathway in ESCC for carcinogenesis and could be a promising target for ESCC therapy.
Other information
Title:

CircRNA_2646 functions as a ceRNA to promote progression of esophageal squamous cell carcinoma via inhibiting miR-124/PLP2 signaling pathway.

Journal: Cell Death Discov
Published: 2021/5/13
PubMed ID: 33976115