circRNA basic information
circBase ID: hsa_circ_0030167
Name: -
Synonym: circ_0030167
Host Gene: hsa-miR-338-5p
 
 
 
Disease basic information
DO ID:
 1793
DO name: pancreatic cancer
Disease details: pancreatic cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human PC cell lines (PANC-1, MIA-PaCa-2, CFPAC1), normal pancreatic ductal epithelial cell line (HPDE6-C7), 293T cell
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DS
Associated gene: Wif1/Wnt8/beta-catenin axis
Associated microRNA: hsa-miR-338-5p
Biological function: regulates miR-338-5p, enhances Wif1 expression, and inhibits the Wnt8/beta-catenin pathway
Molecular mechanism: reduced the invasion, migration, and proliferation of PC cells, as well as tumor stemness
Survival: -
Supported No.:
 1
Description:

BM-MSC exosomal circ_0030167 contributes to the progression and stemness of PC cells via the miR-338-5p/wif1/Wnt 8/beta-catenin axis.
Other information
Title:

Exosomal circ_0030167 derived from BM-MSCs inhibits the invasion, migration, proliferation and stemness of pancreatic cancer cells by sponging miR-338-5p and targeting the Wif1/Wnt8/beta-catenin axis.

Journal: Cancer Lett
Published: 2021/5/11
PubMed ID: 33971282