circRNA basic information
circBase ID: -
Name: -
Synonym: ciRS-7
Host Gene: hsa-miR-1270
 
 
 
Disease basic information
DO ID:
 1733
DO name: cryptosporidiosis
Disease details: cryptosporidiosis
Species: human
Species details: human
Sample type: cell line
Sample type details: HCT-8 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: NF-kappaB signaling pathway
Associated microRNA: hsa-miR-1270
Biological function: promote C. parvum propagation
Molecular mechanism: regulating the hsa-miR-1270/relA axis and affecting the NF-kappaB pathway
Survival: -
Supported No.:
 1
Description:

Our results revealed that ciRS-7 would promote C. parvum propagation by regulating the miR-1270/relA axis and affecting the NF-kappaB pathway. To the best of our knowledge, this is the first study to investigate the role of circRNA during Cryptosporidium infection, and the findings provide a novel view for implementing control strategies against Cryptosporidium infection.
Other information
Title:

Circular RNA ciRS-7 affects the propagation of Cryptosporidium parvum in HCT-8 cells by sponging miR-1270 to activate the NF-kappaB signaling pathway.

Journal: Parasit Vectors
Published: 2021/5/8
PubMed ID: 33957927