circRNA basic information
circBase ID: -
Name: hsa_circ_ZFP644
Synonym: circ_ZFP644
Host Gene: hsa-miR-106b
 
 
 
Disease basic information
DO ID:
 2913
DO name: acute pancreatitis
Disease details: acute pancreatitis
Species: human
Species details: human
Sample type: cell line
Sample type details: AR42J cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: Pias3
Associated microRNA: hsa-miR-106b
Biological function: Enforced expression of circ_ZFP644 or miR-106b inhibition could reduce amylase activity and inflammatory cytokine secretion, while promote apoptosis in caerulein-induced AR42J cells, which was almost reversed by Pias3 knockdown.
Molecular mechanism: Circ_ZFP644 targeted miR-106b to upregulate Pias3 expression.
Survival: -
Supported No.:
 1
Description:

Circ_ZFP644 might exert its anti-inflammation and pro-apoptosis roles in caerulein-induced AR42J cells by regulating miR-106b/Pias3 axis.
Other information
Title:

Circ_ZFP644 attenuates caerulein-induced inflammatory injury in rat pancreatic acinar cells by modulating miR-106b/Pias3 axis.

Journal: Exp Mol Pathol
Published: 2021/5/5
PubMed ID: 33945806