circRNA basic information
circBase ID: hsa_circ_0004831
Name: -
Synonym: -
Host Gene: hsa-miR-182-5p
 
 
 
Disease basic information
DO ID:
 1936
DO name: atherosclerosis
Disease details: atherosclerosis
Species: human
Species details: human
Sample type: cell line
Sample type details: HUVECs
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CXCL12
Associated microRNA: hsa-miR-182-5p
Biological function: ATV promoted cell viability and cell cycle progression but inhibited apoptosis, oxidative stress and inflammation in ox-LDL-treated HUVECs, while the role of ATV was partially reversed by hsa_circ_0004831 overexpression.
Molecular mechanism: MiR-182-5p was targeted by hsa_circ_0004831, and CXCL12 was targeted by miR-182-5p
Survival: -
Supported No.:
 1
Description:

Hsa_circ_0004831-targeted miR-182-5p/CXCL12 regulatory network is one of the pathways by which ATV protects against ox-LDL-induced endothelial injuries
Other information
Title:

Hsa_circ_0004831 downregulation is partially responsible for atorvastatinalleviated human umbilical vein endothelial cell injuries induced by ox-LDL through targeting the miR-182-5p/CXCL12 axis.

Journal: BMC Cardiovasc Disord
Published: 2021/5/3
PubMed ID: 33932991