circRNA basic information
circBase ID: -
Name: hsa_circ_RASSF2
Synonym: CircRASSF2
Host Gene: hsa-miR-195-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: CRC cell lines (DLD-1, HCT116, SW480, SW620)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: FZD4
Associated microRNA: hsa-miR-195-5p
Biological function: CircRASSF2 knockdown could inhibit proliferation, migration, invasion, and enhance apoptosis in CRC cells, and its overexpression had the opposite effect
Molecular mechanism: positively regulate the activity of Wnt/beta-catenin signaling pathway by the hsa-miR-195-5p/FZD4 axis
Survival: poor
Supported No.:
 1
Description:

that circRASSF2 might function as a tumor promoter to accelerate the progression of CRC via regulating the miR-195-5p/FZD4/Wnt/beta-catenin pathway.
Other information
Title:

CircRASSF2 facilitates the proliferation and metastasis of colorectal cancer by mediating the activity of Wnt/beta-catenin signaling pathway by regulating the miR-195-5p/FZD4 axis.

Journal: Anticancer Drugs
Published: 2021/5/1
PubMed ID: 33929991