circRNA basic information
circBase ID: hsa_circ_0062389
Name: hsa_circ_PI4KA
Synonym: -
Host Gene: hsa-miR-1179
 
 
 
Disease basic information
DO ID:
 3969
DO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human PTC cell lines (K-1, SW1736, TPC-1, SW579), human thyroid follicular epithelial cells (Nthy-ori 3_1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: HMGB1
Associated microRNA: hsa-miR-1179
Biological function: Knocking down circ_0062389 could inhibit the proliferation, migration and EMT process of PTC cells
Molecular mechanism: miRNA sponge
Survival: poor
Supported No.:
 1
Description:

The high expression of circ_0062389 was related to large tumor size and positive lymphatic metastasis. Knocking down circ_0062389 could inhibit the proliferation, migration and EMT process of PTC cells. Besides, miR-1179 was a downstream molecule of circ_0062389.
Other information
Title:

Circular RNA circ_0062389 modulates papillary thyroid carcinoma progression via the miR-1179/high mobility group box 1 axis.

Journal: Bioengineered
Published: 2021/5/1
PubMed ID: 33926347