circRNA basic information
circBase ID: -
Name: hsa_circ_PSMA1
Synonym: circPSMA1
Host Gene: hsa-miR-637
 
 
 
Disease basic information
DO ID:
 60081
DO name: triple-receptor negative breast cancer
Disease details: triple-negative breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal breast epithelial cells (MCF-10A), human breast cancer cell line (MCF-7, MDA-MB-231, BT549)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: Akt1/beta-catenin (cyclin D1)
Associated microRNA: hsa-miR-637
Biological function: promotes TNBC cells proliferation and migration and regulates cell cycle and apoptosis
Molecular mechanism: circPSMA1/hsa-miR-637/Akt1-beta-catenin (cyclin D1) regulatory axis
Survival: poor
Supported No.:
 1
Description:

circPSMA1 functions as a tumor promoter through the circPSMA1/miR-637/Akt1-beta-catenin (cyclin D1) regulatory axis, which can facilitate the tumorigenesis, metastasis, and immunosuppression of TNBC.
Other information
Title:

Tumor-derived exosomal circPSMA1 facilitates the tumorigenesis, metastasis, and migration in triple-negative breast cancer (TNBC) through miR-637/Akt1/beta-catenin (cyclin D1) axis.

Journal: Cell Death Dis
Published: 2021/4/30
PubMed ID: 33911067