circRNA basic information
circBase ID: -
Name: -
Synonym: hsa_circRNA_100269
Host Gene: -
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: Four human GC cell lines (AGS, NCI-N87, MKN-45), one normal human gastric epithelial cell line (GES-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PI3K/Akt axis
Associated microRNA: -
Biological function: inhibited the proliferation, migration, invasion and EMT of GC cells, whereas cell cycle arrest at G0/G1 phase was promoted and cell apoptosis was enhanced
Molecular mechanism: inactivating PI3K/Akt axis
Survival: -
Supported No.:
 2
Description:

our findings indicated that the levels of hsa_circRNA_100269 were reduced in GC. Furthermore, hsa_circRNA_100269 could suppress the development of GC by inactivating the PI3K/Akt pathway. More importantly, hsa_circRNA_100269/PI3K/Akt axis may be a novel therapeutic candidate for GC treatment.
Other information
Title:

Upregulated hsa_circRNA_100269 inhibits the growth and metastasis of gastric cancer through inactivating PI3K/Akt axis.

Journal: PLoS One
Published: 2021/4/27
PubMed ID: 33901239