circRNA basic information
circBase ID: hsa_circ_0001018
Name: hsa_circ_CCT4
Synonym: -
Host Gene: hsa-miR-338-3p
 
 
 
Disease basic information
DO ID:
 3969
DO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human PTC cell lines (K1, IHH-4, TPC-1), human thyroid gland undifferentiated carcinoma cell line (CAL-62)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: SOX4
Associated microRNA: hsa-miR-338-3p
Biological function: circ_0001018 and SOX4 promoted cell proliferation, migration, and invasion, inhibited cell apoptosis, and reduced the cell cycle arrest at the G(1) phase in PTC cells
Molecular mechanism: via sponging hsa-miR-338-3p to elevate SOX4 expression level
Survival: -
Supported No.:
 1
Description:

circ_0001018 acted as the tumor promoter via sponging miR-338-3p to elevate SOX4 expression level in PTC.
Other information
Title:

hsa_circ_0001018 promotes papillary thyroid cancer by facilitating cell survival, invasion, G(1)/S cell cycle progression, and repressing cell apoptosis via crosstalk with miR-338-3p and SOX4.

Journal: Mol Ther Nucleic Acids
Published: 2021/4/27
PubMed ID: 33898108