circRNA basic information
circBase ID: hsa_circ_0058357
Name: hsa_circ_ATG9A
Synonym: -
Host Gene: hsa-miR-24-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: H292, A549, H1299, H460
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: AVL9
Associated microRNA: hsa-miR-24-3p
Biological function: Knockdown of hsa_circ_0058357 significantly suppressed cell viability, migration and tumor growth, while it promoted apoptosis in NSCLC cells
Molecular mechanism: hsa_circ_0058357 knockdown contributed to the increase of miR_24_3p expression in NSCLC cells
Survival: -
Supported No.:
 1
Description:

hsa_circ_0058357 may be a crucial regulation factor in NSCLC by sponging hsa_miR_24_3p, leading to a decrease in miR_24_3p expression, and subsequent increase in AVL9 expression. Therefore, hsa_circ_0058357 may serve as a potential target for diagnosis and gene therapy for NSCLC.
Other information
Title:

hsa_circ_0058357 acts as a ceRNA to promote non_small cell lung cancer progression via the hsa_miR_24_3p/AVL9 axis.

Journal: Mol Med Rep
Published: 2021/4/22
PubMed ID: 33880595