circRNA basic information
circBase ID: mmu_circ_0000981
Name: -
Synonym: circRNA-0000981
Host Gene: mmu-miR-211-5p
 
 
 
Disease basic information
DO ID:
 3770
DO name: pulmonary fibrosis
Disease details: pulmonary fibrosis
Species: mouse
Species details: mouse
Sample type: cell line, PDX
Sample type details: TC-1 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TGFBR2
Associated microRNA: mmu-miR-211-5p
Biological function: Atr treatment suppressed OVA-induced circRNA-0000981 and TGFBR2 expression but promoted miR-211-5p expression.
Molecular mechanism: The results also suggested that the downregulation of circRNA-0000981 expression suppressed TGFBR2 by sponging miR-211-5p, which was validated by a luciferase reporter assay.
Survival: -
Supported No.:
 1
Description:

Collectively, the findings of the present study suggest that Atr treatment attenuates PF by regulating the mmu_circ_0000981/miR-211-5p/TGFBR2 axis in an OVA-induced asthma mouse model.
Other information
Title:

Atractylon Treatment Attenuates Pulmonary Fibrosis via Regulation of the mmu_circ_0000981/miR-211-5p/TGFBR2 Axis in an Ovalbumin-Induced Asthma Mouse Model.

Journal: Inflammation
Published: 2021/4/16
PubMed ID: 33855682