circRNA basic information
circBase ID: hsa_circ_0003340
Name: hsa_circ_OGDH
Synonym: -
Host Gene: hsa-miR-615-5p
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: TE-1, Eca-109
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PDX1
Associated microRNA: hsa-miR-615-5p
Biological function: Circ-OGDH inhibition reduced ESCC growth in vivo and accelerated cell apoptosis, cell cycle arrest, repressed cell proliferation, migration, invasion, and reduced cell glutamine metabolism in ESCC cells in vitro
Molecular mechanism: Circ-OGDH sponged hsa-miR-615-5p to regulate PDX1 expression
Survival: -
Supported No.:
 1
Description:

Circ-OGDH sponged miR-615-5p to elevate PDX1 expression, thus elevating glutamine metabolism and promoting tumor growth in ESCC. The study offered evidence to support circ-OGDH as a promising target for ESCC therapy.
Other information
Title:

CircRNA circ-OGDH (hsa_circ_0003340) Acts as a ceRNA to Regulate Glutamine Metabolism and Esophageal Squamous Cell Carcinoma Progression by the miR-615-5p/PDX1 Axis.

Journal: Cancer Manag Res
Published: 2021/4/16
PubMed ID: 33854374