circRNA basic information
circBase ID: -
Name: hsa_circ_OSBPL2
Synonym: -
Host Gene: hsa-miR-193a-5p
 
 
 
Disease basic information
DO ID:
 3083
DO name: chronic obstructive pulmonary disease
Disease details: chronic obstructive pulmonary disease
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: 16HBE
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: BRD4
Associated microRNA: hsa-miR-193a-5p
Biological function: Circ-OSBPL2 down-regulation in HBECs attenuated CSE-evoked cell proliferation arrest, and cell apoptosis, inflammation and oxidative stress promotion
Molecular mechanism: circ-OSBPL2 served as a sponge for hsa-miR-193a-5p, and hsa-miR-193a-5p inhibition reversed the effects of circ-OSBPL2 knockdown on CSE-mediated HBECs
Survival: -
Supported No.:
 2
Description:

Circ-OSBPL2 contributed to the apoptosis, in fl ammation, and oxidative stress of HBECs in smoke-related COPD by miR-193a-5p/BRD4 axis, suggesting a novel insight on the pathogenesis of COPD and a potential therapeutic strategy for future clinic intervention in COPD.
Other information
Title:

Circ-OSBPL2 Contributes to Smoke-Related Chronic Obstructive Pulmonary Disease by Targeting miR-193a-5p/BRD4 Axis.

Journal: Int J Chron Obstruct Pulmon Dis
Published: 2021/4/16
PubMed ID: 33854310