circRNA basic information
circBase ID: hsa_circ_0004136
Name: -
Synonym: circ_0004136
Host Gene: hsa-miR-570-3p
 
 
 
Disease basic information
DO ID:
 9119
DO name: acute myeloid leukemia
Disease details: acute myeloid leukemia
Species: human
Species details: human
Sample type: cell line
Sample type details: HL60, K562
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: TSPAN3
Associated microRNA: hsa-miR-570-3p
Biological function: Circ_0004136 knockdown mediated by exosomes hampered AML cell viability, cell cycle progression, migration and invasion, and promoted cell apoptosis
Molecular mechanism: circ_0004136 worked as a sponge of hsa-miR-570-3p and TSPAN3 was a functional target of hsa-miR-370-3p in AML cells
Survival: -
Supported No.:
 2
Description:

Our findings identified a novel regulatory mechanism in which exosome-mediated circ_0004136 knockdown restrained AML cell malignant progression at least partly through targeting the miR-570-3p/TSPAN3 axis, highlighting a novel therapeutic strategy for AML management.
Other information
Title:

Exosomal circ_0004136 enhances the progression of pediatric acute myeloid leukemia depending on the regulation of miR-570-3p/TSPAN3 axis.

Journal: Anticancer Drugs
Published: 2021/4/15
PubMed ID: 33853086