circRNA basic information
circBase ID: hsa_circ_0114428
Name: -
Synonym: circ_0114428
Host Gene: hsa-miR-495-3p
 
 
 
Disease basic information
DO ID:
 3021
DO name: acute kidney failure
Disease details: acute kidney injury
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human kidney 2 (HK2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CRBN
Associated microRNA: hsa-miR-495-3p
Biological function: Circ_0114428 knockdown attenuated LPS-induced apoptosis, inflammation, oxidative stress, and ER stress, which were rescued by CRBN overexpression.
Molecular mechanism: miR-495-3p was targeted by circ_0114428 and directly bound to CRBN, and circ_0114428 regulated CRBN expression by sponging miR-495-3p.
Survival: -
Supported No.:
 1
Description:

In conclusion, circ_00114428 knockdown attenuated LPS-induced HK2 cell injury by regulating CRBN expression via targeting miR-495-3p.
Other information
Title:

Circ_0114428 Regulates Sepsis-Induced Kidney Injury by Targeting the miR-495-3p/CRBN Axis.

Journal: Inflammation
Published: 2021/4/9
PubMed ID: 33830389